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Article

Mechanisms underlying genetic susceptibility to multisystem inflammatory syndrome in children (MIS-C).

The Journal of allergy and clinical immunology - 1 Sept 2021

Chou Janet, Platt Craig D, Habiballah Saddiq, Nguyen Alan A, Elkins Megan, Weeks Sabrina, Peters Zachary, Day-Lewis Megan, Novak Tanya, Armant Myriam, Williams Lucinda, Rockowitz Shira, Sliz Piotr, Williams David A, Randolph Adrienne G, Geha Raif S

Abstract excerpt

BACKGROUND: Multisystem inflammatory syndrome in children (MIS-C) is a pediatric complication of severe acute respiratory syndrome coronavirus 2 infection that is characterized by multiorgan inflammation and frequently by cardiovascular dysfunction. It occurs predominantly in otherwise healthy children. We previously reported haploinsufficiency of suppressor of cytokine signaling 1 (SOCS1), a negative regulator...

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Identifiers

PMID: 34224783
DOI: 10.1016/j.jaci.2021.06.024
PMCID: PMC8252701

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