Article

Identification of a unique TCR repertoire, consistent with a superantigen selection process in Children with Multi-system Inflammatory Syndrome

2020-11-09

Abstract excerpt

<h4>Summary</h4> Multisystem Inflammatory Syndrome in Children (MIS-C), a hyperinflammatory syndrome associated with SARS-CoV-2 infection, shares many clinical features with toxic shock syndrome, which is triggered by bacterial superantigens. The superantigen specificity for binding different Vβ-chains results in Vβ-skewing, whereby T cells with specific Vβ-chains and diverse antigen specificity are overrepresent...

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Literature Corpus work: ad47b196-7f68-578b-9715-e0a24be9b80e
DOI: 10.1101/2020.11.09.372169

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