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Article

Dimerization activates the Inversin complex in C. elegans.

Molecular biology of the cell - 1 Oct 2024

Beyrent Erika, Wei Derek T, Beacham Gwendolyn M, Park Sangwoo, Zheng Jian, Paszek Matthew J, Hollopeter Gunther

Abstract excerpt

Genetic, colocalization, and biochemical studies suggest that the ankyrin repeat-containing proteins Inversin (INVS) and ANKS6 function with the NEK8 kinase to control tissue patterning and maintain organ physiology. It is unknown whether these three proteins assemble into a static "Inversin complex" or one that adopts multiple bioactive forms. Through the characterization of hyperactive alleles in C. elegans, we...

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Identifiers

PMID: 39110529
DOI: 10.1091/mbc.E24-05-0218
PMCID: PMC11481705

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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