Article
Retinophilin is a light-regulated phosphoprotein required to suppress photoreceptor dark noise in Drosophila.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Jan 2010
Mecklenburg Kirk L, Takemori Nobuaki, Komori Naoka, Chu Brian, Hardie Roger C, Matsumoto Hiroyuki, O'Tousa Joseph E
Abstract excerpt
Photoreceptor cells achieve high sensitivity, reliably detecting single photons, while limiting the spontaneous activation events responsible for dark noise. We used proteomic, genetic, and electrophysiological approaches to characterize Retinophilin (RTP) (CG10233) in Drosophila photoreceptors and establish its involvement in dark-noise suppression. RTP possesses membrane occupation and recognition nexus (MORN)...
Topics
- Adaptation, Ocular
- Amino Acid Motifs
- Animals
- Animals, Genetically Modified
- Dark Adaptation
- Drosophila Proteins
- Drosophila melanogaster
- Eye
- Eye Proteins
- Light
- Membrane Potentials
- Microvilli
- Mutation