Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Using polygenic risk modification to improve breast cancer prevention: study protocol for the PRiMo multicentre randomised controlled trial.

BMJ open - 5 Aug 2024

McInerny Simone, Mascarenhas Lyon, Yanes Tatiane, Petelin Lara, Chenevix-Trench Georgia, Southey Melissa C, Young Mary-Anne, James Paul A

Abstract excerpt

INTRODUCTION: Established personal and familial risk factors contribute collectively to a woman's risk of breast or ovarian cancer. Existing clinical services offer genetic testing for pathogenic variants in high-risk genes to investigate these risks but recent information on the role of common genomic variants, in the form of a Polygenic Risk Score (PRS), has provided the potential to further personalise breast...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Australia
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Testing

Share to Multicenter Studies as Topic

Share to Multifactorial Inheritance

Share to Ovarian Neoplasms

Share to Randomized Controlled Trials as Topic

Share to Risk Assessment

Source

Open in PubMed Open full text

Identifiers

PMID: 39107016
DOI: 10.1136/bmjopen-2024-087874
PMCID: PMC11308879

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Using polygenic risk modification to improve breast cancer prevention: study protocol for the PRiMo multicentre randomised controlled trial.PMID 39107016Read ↗

Psychosocial and behavioral impact of breast cancer risk assessed by testing for common risk variants: protocol of a prospective study.Semantic proximity Read ↗

Polygenic risk scores and breast cancer risk prediction.Semantic proximity Read ↗

Polygenic risk scores to refine Breast cancer screening and prevention strategies.Semantic proximity Read ↗

A clinical pilot study for personalized risk-based breast cancer screening utilizing a polygenic risk score.Semantic proximity Read ↗

A clinical pilot study for personalized risk-based breast cancer screening utilizing the polygenic risk scoreSemantic proximity Read ↗

Development and Validation of a Clinical Polygenic Risk Score to Predict Breast Cancer RiskSemantic proximity Read ↗

Polygenic Risk Scores for Breast Cancer: Modern Approaches to Risk Prediction and Subtype Identification.Semantic proximity Read ↗

A role for common genomic variants in the assessment of familial breast cancer.Semantic proximity Read ↗

Integrating breast cancer polygenic risk scores at scale in the WISDOM Study: a national randomized personalized screening trial.Semantic proximity Read ↗

Prospective Evaluation of a Breast Cancer Risk Model Integrating Classical Risk Factors and Polygenic Risk in 15 Cohorts from Six CountriesSemantic proximity Read ↗

Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers.Semantic proximity Read ↗

Breast cancer risk prediction using a polygenic risk score in the familial setting: a prospective study from the Breast Cancer Family Registry and kConFab.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.