Article
Psychosocial and behavioral impact of breast cancer risk assessed by testing for common risk variants: protocol of a prospective study.
BMC cancer - 18 Jul 2017
Yanes Tatiane, Meiser Bettina, Young Mary-Anne, Kaur Rajneesh, Mitchell Gillian, Barlow-Stewart Kristine, Roscioli Tony, Halliday Jane, James Paul
Abstract excerpt
BACKGROUND: The 'common variant, common disease' model predicts that a significant component of hereditary breast cancer unexplained by pathogenic variants in moderate or high-penetrance genes is due to the cumulative effect of common risk variants in DNA (polygenic risk). Assessing a woman's breast cancer risk by testing for common risk variants can provide useful information for women who would otherwise...
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