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Article

A clinical pilot study for personalized risk-based breast cancer screening utilizing a polygenic risk score.

PloS one - 1 Jan 2026

Hovda Tone, Sober Siim, Padrik Peeter, Kruuv-Kao Krista, Grindedal Eli Marie, Vamre Tone Bøe Aaman, Eikeland Eline, Hofvind Solveig, Sahlberg Kristine Kleivi

Abstract excerpt

BACKGROUND: Population-based mammographic screening is primarily age-based. However, breast cancer risk is multifactorial, and women may benefit from personalized risk-based screening. This pilot study aimed to explore the use of polygenic risk score (PRS) as a tool for risk stratification in personalized screening. METHODS: We included 80 women aged 40-49 years referred for clinical mammography. Exclusion...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42418475
DOI: 10.1371/journal.pone.0345431
PMCID: PMC13345395

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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