PRS-BC313 integration for tailored breast cancer prevention in female patients and their healthy relatives.

doi:10.1136/jmg-2025-111211

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Article

PRS-BC313 integration for tailored breast cancer prevention in female patients and their healthy relatives.

Journal of medical genetics - 26 Aug 2026

Krakowsky Rosanna H E, Drukewitz Stephan, Händel Alexandra, Wiedenhöft John, Aktas Bahriye, Lemke Johannes R, Strehlow Vincent, Hentschel Julia

Abstract excerpt

Precise breast cancer risk assessment (BCR) is essential for personalised prevention in women with a family history of hereditary breast and ovarian cancer (HBOC). The CanRisk model integrates monogenic variants with reproductive, lifestyle and familial factors and can be extended by Polygenic Risk Scores (PRS). We evaluated the impact of PRS-BC313 in three groups: (1) healthy carriers of (likely) pathogenic...

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PMID: 42248667
DOI: 10.1136/jmg-2025-111211
PMCID: PMC13539864

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