Integrating breast cancer polygenic risk scores at scale in the WISDOM Study: a national randomized personalized screening trial.

doi:10.1186/s13073-025-01524-7

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Integrating breast cancer polygenic risk scores at scale in the WISDOM Study: a national randomized personalized screening trial.

Genome medicine - 28 Aug 2025

Fergus Kirkpatrick B, Heise Rachel S, Madlensky Lisa, Fiscalini Allison, Sabacan Leah, Theiner Sarah, Kapoor Shreya, Soto Irene A, Blanco Amie, Ross Katherine, Goodman-Gruen Deborah, Scheuner Maren, Hu Donglei, Heditsian Diane, Brain Susie, Arasu Vignesh A, Kaster Andrea, Chapa Lisa, Olopade Olufunmilayo I, Eklund Martin, Tice Jeffrey A, Ziv Elad, van 't Veer Laura, Esserman Laura J, Shieh Yiwey

Abstract excerpt

BACKGROUND: The Women Informed to Screen Depending On Measures of risk (WISDOM) Study is the first prospective, population-wide application of personalized breast cancer screening. We aim to demonstrate the feasibility of the study's novel use of polygenic risk scores (PRSs) to tailor screening, evaluate our strategy for adapting PRSs to diverse populations, and quantify the impact of incorporating PRS on the...

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PMID: 40877879
DOI: 10.1186/s13073-025-01524-7
PMCID: PMC12395744

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