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Article

Prevalence of KRAS amplification in patients with metastatic cancer: Real-world next-generation sequencing analysis.

Pathology, research and practice - 1 Sept 2024

Choi Dae-Ho, Jang Hye-Lim, Lim Sung Hee, Kim Seung Tae, Hong Jung Yong, Park Se Hoon, Park Joon Oh, Kim Deok Geun, Kim Kyoung-Mee, Lee Jeeyun

Abstract excerpt

BACKGROUND: The Kirsten rat sarcoma virus (KRAS) is a prominent proto-oncogene. Several treatments for KRAS mutations have been developed. However, KRAS amplification, a KRAS alteration, is poorly understood, and there is currently no appropriate treatment other than conventional chemotherapy. This study aimed to elucidate the role of KRAS amplification in different types of cancers. METHODS: From October 2019 to...

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Identifiers

PMID: 39106591
DOI: 10.1016/j.prp.2024.155473

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