Article
Extensive genomic analysis in patients with KRAS-mutated solid tumors shows high frequencies of concurrent alterations and potential targets but has limited clinical impact.
Acta oncologica (Stockholm, Sweden) - 1 Dec 2022
Jacobsen Ida Christine, Spanggaard Iben, Højgaard Martin, Belcaid Laïla, Qvortrup Camilla, Yde Christina Westmose, Schmidt Ane Yde, Nielsen Finn Cilius, Willemoe Gro Linno, Dam Mikkel Seidelin, Lassen Ulrik, Staal Rohrberg Kristoffer
Abstract excerpt
BACKGROUND: This study aimed to investigate the distribution and frequency of concurrent alterations in different cancers across KRAS subtypes and in different KRAS subtypes across cancers, and to identify potentially actionable targets and patients who received targeted treatment matched to their genomic profile (GP). MATERIALS AND METHODS: In this descriptive and single-center study, we included 188 patients...
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