Article
A pleiotropic variant in DNAJB4 is associated with multiple myeloma risk.
International journal of cancer - 15 Jan 2023
Dicanio Marco, Giaccherini Matteo, Clay-Gilmour Alyssa, Macauda Angelica, Sainz Juan, Machiela Mitchell J, Rybicka-Ramos Malwina, Norman Aaron D, Tyczyńska Agata, Chanock Stephen J, Barington Torben, Kumar Shaji K, Bhatti Parveen, Cozen Wendy, Brown Elizabeth E, Suska Anna, Haastrup Eva K, Orlowski Robert Z, Dudziński Marek, Garcia-Sanz Ramon, Kruszewski Marcin, Martinez-Lopez Joaquin, Beider Katia, Iskierka-Jazdzewska Elżbieta, Pelosini Matteo, Berndt Sonja I, Raźny Małgorzata, Jamroziak Krzysztof, Rajkumar S Vincent, Jurczyszyn Artur, Vangsted Annette Juul, Collado Pilar Garrido, Vogel Ulla, Hofmann Jonathan N, Petrini Mario, Butrym Aleksandra, Slager Susan L, Ziv Elad, Subocz Edyta, Giles Graham G, Andersen Niels Frost, Mazur Grzegorz, Watek Marzena, Lesueur Fabienne, Hildebrandt Michelle A T, Zawirska Daria, Ebbesen Lene Hyldahl, Marques Herlander, Gemignani Federica, Dumontet Charles, Várkonyi Judit, Buda Gabriele, Nagler Arnon, Druzd-Sitek Agnieszka, Wu Xifeng, Kadar Katalin, Camp Nicola J, Grzasko Norbert, Waller Rosalie G, Vachon Celine, Canzian Federico, Campa Daniele
Abstract excerpt
Pleiotropy, which consists of a single gene or allelic variant affecting multiple unrelated traits, is common across cancers, with evidence for genome-wide significant loci shared across cancer and noncancer traits. This feature is particularly relevant in multiple myeloma (MM) because several susceptibility loci that have been identified to date are pleiotropic. Therefore, the aim of this study was to identify...
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