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Article

Glycosaminoglycan binding properties of the myxoma virus CC-chemokine inhibitor, M-T1.

The Journal of biological chemistry - 10 Aug 2001

Seet B T, Barrett J, Robichaud J, Shilton B, Singh R, McFadden G

Abstract excerpt

Poxviruses encode a number of secreted virulence factors that function to mitigate or modulate the host immune response. M-T1 is a secreted 43-kDa glycoprotein produced by the myxoma virus, a poxvirus pathogen of rabbits, that binds CC-chemokines with high affinity, blocks binding to their cognate G-protein coupled receptors, and thereby inhibits chemokine-induced leukocyte chemotaxis. The present study indicates...

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PMID: 11369757
DOI: 10.1074/jbc.M011401200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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