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Article

Defective transfer of parental histone decreases frequency of homologous recombination by increasing free histone pools in budding yeast.

Nucleic acids research - 22 May 2024

Karri Srinivasu, Yang Yi, Zhou Jiaqi, Dickinson Quinn, Jia Jing, Huang Yuxin, Wang Zhiquan, Gan Haiyun, Yu Chuanhe

Abstract excerpt

Recycling of parental histones is an important step in epigenetic inheritance. During DNA replication, DNA polymerase epsilon subunit DPB3/DPB4 and DNA replication helicase subunit MCM2 are involved in the transfer of parental histones to the leading and lagging strands, respectively. Single Dpb3 deletion (dpb3Δ) or Mcm2 mutation (mcm2-3A), which each disrupts one parental histone transfer pathway, leads to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38554108
DOI: 10.1093/nar/gkae205
PMCID: PMC11109958

Genes

MCM2

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