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Article

Infection-Sensitive SPION/PLGA Scaffolds Promote Periodontal Regeneration via Antibacterial Activity and Macrophage-Phenotype Modulation.

ACS applied materials & interfaces - 14 Aug 2024

Guo Yu, Shi Zihan, Han Liping, Qin Xuan, You Jiayi, Zhang Qian, Chen Xichen, Zhao Yantao, Sun Jianfei, Xia Yang

Abstract excerpt

Inflammation caused by a bacterial infection and the subsequent dysregulation of the host immune-inflammatory response are detrimental to periodontal regeneration. Herein, we present an infection-sensitive scaffold prepared by layer-by-layer assembly of Feraheme-like superparamagnetic iron oxide nanoparticles (SPIONs) on the surface of a three-dimensional-printed polylactic-co-glycolic acid (PLGA) scaffold. The...

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PMID: 39093305
DOI: 10.1021/acsami.4c06430

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