Article
Remotely Temporal Scheduled Macrophage Phenotypic Transition Enables Optimized Immunomodulatory Bone Regeneration.
Small (Weinheim an der Bergstrasse, Germany) - 1 Sept 2022
Huang Donghua, Xu Kaicheng, Huang Xin, Lin Nong, Ye Yuxiao, Lin Suya, Zhang Jiamin, Shao Jiaqi, Chen Songfeng, Shi Mingmin, Zhou Xingzhi, Lin Peng, Xue Yucheng, Yu Chengcheng, Yu Xiaohua, Ye Zhaoming, Cheng Kui
Abstract excerpt
Precise timing of macrophage polarization plays a pivotal role in immunomodulation of tissue regeneration, yet most studies mainly focus on M2 macrophages for their anti-inflammatory and regenerative effects while the essential proinflammatory role of the M1 phenotype on the early inflammation stage is largely underestimated. Herein, a superparamagnetic hydrogel capable of timely controlling macrophage...
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