Drug-induced hepatotoxicity and association with slow acetylation variants NAT2*5 and NAT2*6 in Cameroonian patients with tuberculosis and HIV co-infection.

doi:10.1186/s12879-024-09638-w

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Article

Drug-induced hepatotoxicity and association with slow acetylation variants NAT25 and NAT26 in Cameroonian patients with tuberculosis and HIV co-infection.

BMC infectious diseases - 31 Jul 2024

Cho Frederick Nchang, Achidi Eric A, Enoh Jude Eteneneng, Pallerla Srinivas Reddy, Linh Le Thi Kieu, Tong Hoang Van, Kamgno Joseph, Penlap Véronique Beng, Adegnika Ayola Akim, Lekana-Douki Jean-Bernard, Bouyou-Akotet Marielle Karine, Kahunu Gauthier Mesia, Lutete Gaston Tona, Bates Mathew, Tembo John, Elton Linzy, McHugh Timothy D, Grobusch Martin P, Zumla Alimuddin, Ntoumi Francine, Velavan Thirumalaisamy P

Abstract excerpt

BACKGROUND: Human immunodeficiency virus (HIV) and tuberculosis (TB) are major contributors to morbidity and mortality in sub-Saharan Africa including Cameroon. Pharmacogenetic variants could serve as predictors of drug-induced hepatotoxicity (DIH), in patients with TB co-infected with HIV. We evaluated the occurrence of DIH and pharmacogenetic variants in Cameroonian patients. METHODS: Treatment-naïve patients...

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Identifiers

PMID: 39085767
DOI: 10.1186/s12879-024-09638-w
PMCID: PMC11293078

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