Article
NAT2 polymorphisms associated with the development of hepatotoxicity after first-line tuberculosis treatment in Mexican patients: From genotype to molecular structure characterization.
Clinica chimica acta; international journal of clinical chemistry - 1 Aug 2021
Herrera-Rodulfo Aldo, Carrillo-Tripp Mauricio, Laura Yeverino-Gutierrez Myrna, Peñuelas-Urquides Katia, Adiene González-Escalante Laura, Bermúdez de León Mario, Silva-Ramirez Beatriz
Abstract excerpt
BACKGROUND AND AIMS: To assess the relevance of the slow acetylator phenotype based on NAT2 genotypes, among patients with pulmonary tuberculosis (PTB) that developed hepatotoxicity after first-line tuberculosis treatment in a Northeastern Mexican population. METHODS: Ninety one PTB patients were included, 7 of them developed hepatotoxicity. NAT2 SNPs (rs1801279, rs1041983, rs1801280, rs1799929, rs1799930,...