Article
Direct comparison of non-osteoarthritic and osteoarthritic synovial fluid-induced intracellular chondrocyte signaling and phenotype changes.
Osteoarthritis and cartilage - 1 Jan 2023
Housmans B A C, van den Akker G G H, Neefjes M, Timur U T, Cremers A, Peffers M J, Caron M M J, van Rhijn L W, Emans P J, Boymans T A E J, Feczko P Z, van der Kraan P M, Welting T J M
Abstract excerpt
OBJECTIVE: Since the joint microenvironment and tissue homeostasis are highly dependent on synovial fluid, we aimed to compare the essential chondrocyte signaling signatures of non-osteoarthritic vs end-stage osteoarthritic knee synovial fluid. Moreover, we determined the phenotypic consequence of the distinct signaling patterns on articular chondrocytes. METHODS: Protein profiling of synovial fluid was performed...
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