Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Using deep learning to decipher the impact of telomerase promoter mutations on the dynamic metastatic morpholome.

PLoS computational biology - 1 Jul 2024

Nevarez Andres J, Mudla Anusorn, Diaz Sabrina A, Hao Nan

Abstract excerpt

Melanoma showcases a complex interplay of genetic alterations and intra- and inter-cellular morphological changes during metastatic transformation. While pivotal, the role of specific mutations in dictating these changes still needs to be fully elucidated. Telomerase promoter mutations (TERTp mutations) significantly influence melanoma's progression, invasiveness, and resistance to various emerging treatments,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Computational Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Deep Learning

Share to Melanoma

Share to Neoplasm Metastasis

Share to Promoter Regions, Genetic

Share to Skin Neoplasms

Share to Telomerase

Source

Open in PubMed Open full text

Identifiers

PMID: 39078811
DOI: 10.1371/journal.pcbi.1012271
PMCID: PMC11288469

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Using deep learning to decipher the impact of telomerase promoter mutations on the dynamic metastatic morpholome.PMID 39078811Read ↗

TERT expression is associated with metastasis from thin primaries, exhausted CD4+ T cells in melanoma and with DNA repair across cancer entities.Semantic proximity Read ↗

<i>TERT</i> expression is associated with metastasis from thin primaries, exhausted CD4+ T cells in melanoma and with DNA repair across cancer entitiesSemantic proximity Read ↗

TERT Promoter Mutations and Telomerase in MelanomaSemantic proximity Read ↗

Stepwise-edited, human melanoma models reveal mutations' effect on tumor and microenvironment.Semantic proximity Read ↗

Spatial determinants of tumor cell dedifferentiation and plasticity in primary cutaneous melanomaSemantic proximity Read ↗

Transglutaminase Type 2-MITF axis regulates phenotype switching in skin cutaneous melanoma.Semantic proximity Read ↗

Genetic and Genomic Pathways of Melanoma Development, Invasion and Metastasis.Semantic proximity Read ↗

Predicting targeted- and immunotherapeutic response outcomes in melanoma with single-cell Raman spectroscopy and AISemantic proximity Read ↗

Unmasking the "targetless" illusion: branched clonal evolution of TERT and KIT in acral melanoma revealed by sequential multi-site biopsies- a case report.Semantic proximity Read ↗

Understanding Molecular Mechanisms of Phenotype Switching and Crosstalk with TME to Reveal New Vulnerabilities of Melanoma.Semantic proximity Read ↗

Label-Free Melanoma Phenotype Classification Using Artificial Intelligence-Based Morphological ProfilingSemantic proximity Read ↗

MAPK Pathway and TERT Promoter Gene Mutation Pattern and Its Prognostic Value in Melanoma Patients: A Retrospective Study of 2,793 Cases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.