Article
Stepwise-edited, human melanoma models reveal mutations' effect on tumor and microenvironment.
Science (New York, N.Y.) - 29 Apr 2022
Hodis Eran, Torlai Triglia Elena, Kwon John Y H, Biancalani Tommaso, Zakka Labib R, Parkar Saurabh, Hütter Jan-Christian, Buffoni Lorenzo, Delorey Toni M, Phillips Devan, Dionne Danielle, Nguyen Lan T, Schapiro Denis, Maliga Zoltan, Jacobson Connor A, Hendel Ayal, Rozenblatt-Rosen Orit, Mihm Martin C, Garraway Levi A, Regev Aviv
Abstract excerpt
Establishing causal relationships between genetic alterations of human cancers and specific phenotypes of malignancy remains a challenge. We sequentially introduced mutations into healthy human melanocytes in up to five genes spanning six commonly disrupted melanoma pathways, forming nine genetically distinct cellular models of melanoma. We connected mutant melanocyte genotypes to malignant cell expression...
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