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Article

Human GABARAP can restore autophagosome biogenesis in a C. elegans lgg-1 mutant.

Autophagy - 1 Oct 2014

Jenzer Céline, Manil-Ségalen Marion, Lefebvre Christophe, Largeau Céline, Glatigny Annie, Legouis Renaud

Abstract excerpt

We recently described in C. elegans embryos, the acquisition of specialized functions for orthologs of yeast Atg8 (e.g., mammalian MAP1LC3/LC3) in allophagy, a selective and developmentally regulated autophagic process. During the formation of double-membrane autophagosomes, the ubiquitin-like Atg8/LC3 proteins are recruited to the membrane through a lipidation process. While at least 6 orthologs and paralogs are...

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Identifiers

PMID: 25126728
DOI: 10.4161/auto.29745
PMCID: PMC4198372

Genes

GABARAP
GABARAPL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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