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Article

5' preS1 Mutations To Prevent Large Envelope Protein Expression from Hepatitis B Virus Genotype A or Genotype D Markedly Increase Polymerase-Envelope Fusion Protein.

Journal of virology - 9 Mar 2022

Zhang Jing, Yuan Quan, Wang Yongxiang, Wang Yuzhou, Yuan Wenqing, Xia Ningshao, Wen Yumei, Li Jisu, Tong Shuping

Abstract excerpt

Hepatitis B virus (HBV) large (L) envelope protein is translated from 2.4-kb RNA. It contains preS1, preS2, and S domains and is detected in Western blotting as p39 and gp42. The 3.5-kb pregenomic RNA produces core and polymerase (P) proteins. We generated L-minus mutants of a genotype A clone and a genotype D clone from 1.1-mer or 1.3-mer construct, with the former overproducing pregenomic RNA. Surprisingly,...

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Identifiers

PMID: 35019714
DOI: 10.1128/JVI.01723-21
PMCID: PMC8906437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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