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Genetic Variation of the Kinases That Phosphorylate Tenofovir and Emtricitabine in Peripheral Blood Mononuclear Cells.

AIDS research and human retroviruses - 1 May 2018

Figueroa Dominique B, Madeen Erin P, Tillotson Joseph, Richardson Paul, Cottle Leslie, McCauley Marybeth, Landovitz Raphael J, Andrade Adriana, Hendrix Craig W, Mayer Kenneth H, Wilkin Timothy, Gulick Roy M, Bumpus Namandjé N

Abstract excerpt

Tenofovir (TFV) disoproxil fumarate and emtricitabine (FTC) are used in combination for HIV treatment and pre-exposure prophylaxis (PrEP). TFV disoproxil fumarate is a prodrug that undergoes diester hydrolysis to TFV. FTC and TFV are nucleoside/nucleotide reverse transcriptase inhibitors that upon phosphorylation to nucleotide triphosphate analogs competitively inhibit HIV reverse transcriptase. We previously...

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Identifiers

PMID: 29455571
DOI: 10.1089/AID.2017.0243
PMCID: PMC5934973

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