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Article

Discovery of genetic variants of the kinases that activate tenofovir among individuals in the United States, Thailand, and South Africa: HPTN067.

PloS one - 1 Jan 2018

Figueroa Dominique B, Tillotson Joseph, Li Maoji, Piwowar-Manning Estelle, Hendrix Craig W, Holtz Timothy H, Bokoch Kevin, Bekker Linda-Gail, van Griensven Frits, Mannheimer Sharon, Hughes James P, Grant Robert M, Bumpus Namandjé N

Abstract excerpt

Tenofovir (TFV), a nucleotide reverse transcriptase inhibitor, requires two phosphorylation steps to form a competitive inhibitor of HIV reverse transcriptase. Adenylate kinase 2 (AK2) has been previously demonstrated to phosphorylate tenofovir to tenofovir-monophosphate, while creatine kinase, muscle (CKM), pyruvate kinase, muscle (PKM) and pyruvate kinase, liver and red blood cell (PKLR) each have been found to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29641561
DOI: 10.1371/journal.pone.0195764
PMCID: PMC5895070

Genes

CKM
PKLR
PKM

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