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Vitamin D Decreases Susceptibility of CD4+ T Cells to HIV Infection by Reducing AKT Phosphorylation and Glucose Uptake: A Bioinformatic and In Vitro Approach

2024-12-24

Abstract excerpt

Activated immune cells are highly susceptible to human immunodeficiency virus (HIV) infection. Vitamin D (VitD) induces antimicrobial responses and reduces cellular activation. We investigated VitD effects on HIV-1 replication, glucose uptake, and gene regulation using computational and in vitro approaches. CD4+ T-cells from healthy male donors were treated with VitD and infected with HIV-1. After 72 hours, p24 pr...

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Literature Corpus work
d3ba2a6c-e340-52f9-9f54-016b7d008043
DOI
10.20944/preprints202412.2098.v1
Open publication

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Vitamin D Decreases Susceptibility of CD4+ T Cells to HIV Infection by Reducing AKT Phosphorylation and Glucose Uptake: A Bioinformatic and In Vitro ApproachDOI 10.20944/preprints202412.2098.v1
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