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Article

HBsAg level defines different clinical phenotypes of HBeAg(-) chronic HBV infection related to HBV polymerase-specific CD8+ cell response quality.

Frontiers in immunology - 1 Jan 2024

Peña-Asensio Julia, Calvo-Sánchez Henar, Miquel-Plaza Joaquín, Sanz-de-Villalobos Eduardo, González-Praetorius Alejandro, Delgado-Fernandez Alberto, Torralba Miguel, Larrubia Juan-Ramón

Abstract excerpt

Background: HBe-antigen(Ag)-negative chronic hepatitis B virus (HBV) infection is characterized by little liver fibrosis progression and vigorous HBV-multispecific CD8+ T-cell response. Aims: To assess whether HBsAg level could discriminate different HBeAg-negative chronic HBV infection subtypes with dissimilar quality of HBV-specific CD8+ T-cell response. Methods: We recruited 63 HBeAg-negative chronic HBV...

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Identifiers

PMID: 38545116
DOI: 10.3389/fimmu.2024.1352929
PMCID: PMC10966405

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