Article
Oligonucleotide ligation assay detects HIV drug resistance associated with virologic failure among antiretroviral-naive adults in Kenya.
Journal of acquired immune deficiency syndromes (1999) - 1 Nov 2014
Chung Michael H, Beck Ingrid A, Dross Sandra, Tapia Kenneth, Kiarie James N, Richardson Barbra A, Overbaugh Julie, Sakr Samah R, John-Stewart Grace C, Frenkel Lisa M
Abstract excerpt
BACKGROUND: Transmitted drug resistance (TDR) is increasing in some areas of Africa. Detection of TDR may predict virologic failure of first-line nonnucleoside reverse transcriptase inhibitor (NNRTI)-based antiretroviral therapy (ART). We evaluated the utility of a relatively inexpensive oligonucleotide ligation assay (OLA) to detect clinically relevant TDR at the time of ART initiation. METHODS: Pre-ART plasmas...
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