Article
Potential Role of APOBEC3 Family Proteins in SARS-CoV-2 Replication.
Viruses - 16 Jul 2024
Begum Mst Monira, Bokani Ayub, Rajib Samiul Alam, Soleimanpour Mohadeseh, Maeda Yosuke, Yoshimura Kazuhisa, Satou Yorifumi, Ebrahimi Diako, Ikeda Terumasa
Abstract excerpt
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has acquired multiple mutations since its emergence. Analyses of the SARS-CoV-2 genomes from infected patients exhibit a bias toward C-to-U mutations, which are suggested to be caused by the apolipoprotein B mRNA editing enzyme polypeptide-like 3 (APOBEC3, A3) cytosine deaminase proteins. However, the role of A3 enzymes in SARS-CoV-2 replication remains...
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