Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitness.

Scientific reports - 13 Sept 2022

Kim Kyumin, Calabrese Peter, Wang Shanshan, Qin Chao, Rao Youliang, Feng Pinghui, Chen Xiaojiang S

Abstract excerpt

During COVID-19 pandemic, mutations of SARS-CoV-2 produce new strains that can be more infectious or evade vaccines. Viral RNA mutations can arise from misincorporation by RNA-polymerases and modification by host factors. Analysis of SARS-CoV-2 sequence from patients showed a strong bias toward C-to-U mutation, suggesting a potential mutational role by host APOBEC cytosine deaminases that possess broad anti-viral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to APOBEC Deaminases
Share to Caco-2 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to COVID-19

Share to Cytidine Deaminase

Share to Pandemics

Share to RNA Editing

Share to RNA, Viral

Share to SARS-CoV-2

Source

Open in PubMed Open full text

Identifiers

PMID: 36100631
DOI: 10.1038/s41598-022-19067-x
PMCID: PMC9470679

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitness.PMID 36100631Read ↗

The Roles of APOBEC-mediated RNA Editing in SARS-CoV-2 Mutations, Replication and FitnessSemantic proximity Read ↗

The Roles of APOBEC-mediated RNA Editing in SARS-CoV-2 Mutations, Replication and FitnessSemantic proximity Read ↗

Cellular APOBEC3A deaminase drives mutations in the SARS-CoV-2 genome.Semantic proximity Read ↗

Potential APOBEC-mediated RNA editing of the genomes of SARS-CoV-2 and other coronaviruses and its impact on their longer term evolution.Semantic proximity Read ↗

The continuing discovery on the evidence for RNA editing in SARS-CoV-2.Semantic proximity Read ↗

Potential Role of APOBEC3 Family Proteins in SARS-CoV-2 ReplicationSemantic proximity Read ↗

The role of A-to-I RNA editing in infections by RNA viruses: Possible implications for SARS-CoV-2 infection.Semantic proximity Read ↗

Potential Role of APOBEC3 Family Proteins in SARS-CoV-2 Replication.Semantic proximity Read ↗

Point mutation bias in SARS-CoV-2 variants results in increased ability to stimulate inflammatory responsesSemantic proximity Read ↗

Point mutation bias in SARS-CoV-2 variants results in increased ability to stimulate inflammatory responsesSemantic proximity Read ↗

Evidence Supporting That C-to-U RNA Editing Is the Major Force That Drives SARS-CoV-2 Evolution.Semantic proximity Read ↗

Host-dependent C-to-U RNA editing in SARS-CoV-2 creates novel viral genes with optimized expressibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.