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Article

Cellular APOBEC3A deaminase drives mutations in the SARS-CoV-2 genome.

Nucleic acids research - 25 Jan 2023

Nakata Yoshihiro, Ode Hirotaka, Kubota Mai, Kasahara Takaaki, Matsuoka Kazuhiro, Sugimoto Atsuko, Imahashi Mayumi, Yokomaku Yoshiyuki, Iwatani Yasumasa

Abstract excerpt

The number of genetic variations in the SARS-CoV-2 genome has been increasing primarily due to continuous viral mutations. Here, we report that the human APOBEC3A (A3A) cytidine deaminase plays a critical role in the induction of C-to-U substitutions in the SARS-CoV-2 genome. Bioinformatic analysis of the chronological genetic changes in a sequence database indicated that the largest UC-to-UU mutation signature,...

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Identifiers

PMID: 36610792
DOI: 10.1093/nar/gkac1238
PMCID: PMC9881129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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