Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex.

doi:10.1038/s41401-020-00605-0

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Article

Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex.

Acta pharmacologica Sinica - 1 Oct 2021

Li Xiao-Jing, Zhang Yuan-Yuan, Fu Yu-Hua, Zhang Hao, Li He-Xuan, Li Quan-Fu, Li Hai-Ling, Tan Ren-Ke, Jiang Chen-Xiao, Jiang Wei, Li Zeng-Xia, Luo Cheng, Lu Bo-Xun, Dang Yong-Jun

Abstract excerpt

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by toxic aggregates of mutant huntingtin protein (mHTT) in the brain. Decreasing mHTT is a potential strategy for therapeutic purpose of HD. Valosin-containing protein (VCP/p97) is a crucial regulator of proteostasis, which regulates the degradation of damaged protein through proteasome and autophagy pathway. Since VCP has been...

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PMID: 33495516
DOI: 10.1038/s41401-020-00605-0
PMCID: PMC8463700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.