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Article

The regulation of N-terminal Huntingtin (Htt552) accumulation by Beclin1.

Acta pharmacologica Sinica - 1 Jun 2012

Wu Jun-chao, Qi Lin, Wang Yan, Kegel Kimberly B, Yoder Jennifer, Difiglia Marian, Qin Zheng-hong, Lin Fang

Abstract excerpt

AIM: Huntingtin protein (Htt) was a neuropathological hallmark in human Huntington's Disease. The study aimed to investigate whether the macroautophagy regulator, Beclin1, was involved in the degradation of Htt. METHODS: PC12 cells and primary cultured brain neurons of rats were examined. pDC316 adenovirus shuttle plasmid was used to mediate the expression of wild-type Htt-18Q-552 or mutant Htt-100Q-552 in PC12...

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Identifiers

PMID: 22543707
DOI: 10.1038/aps.2012.14
PMCID: PMC4010368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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