Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of ubiquitin C-terminal hydrolase L1 in neurodegenerative disorders.

Drug news & perspectives - 1 Jan 2000

Gong Bing, Leznik Elena

Abstract excerpt

Impairment of the ubiquitin-proteasome system (UPS) results in the failure to remove and degrade misfolded proteins and consequently causes the accumulation of misfolded proteins in the cell. The aberrant interactions between misfolded proteins and normal intracellular proteins are thought to underlie the pathogenesis in many neurodegenerative diseases. Ubiquitin C-terminal hydrolase L1 (UCH-L1) is an important...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Drug Delivery Systems
Share to Huntington Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Parkinson Disease

Share to Proteasome Endopeptidase Complex

Share to Ubiquitin Thiolesterase

Source

Identifiers

PMID: 17925890
DOI: 10.1358/dnp.2007.20.6.1138160

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of ubiquitin C-terminal hydrolase L1 in neurodegenerative disorders.PMID 17925890Read ↗

The functions of UCH-L1 and its relation to neurodegenerative diseases.Semantic proximity Read ↗

Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivoSemantic proximity Read ↗

Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases.Semantic proximity Read ↗

Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome system.Semantic proximity Read ↗

Control of BACE1 degradation and APP processing by ubiquitin carboxyl-terminal hydrolase L1.Semantic proximity Read ↗

Familial Mutations and Post-translational Modifications of UCH-L1 in Parkinson's Disease and Neurodegenerative Disorders.Semantic proximity Read ↗

Novel UCHL1 mutations reveal new insights into ubiquitin processing.Semantic proximity Read ↗

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.Semantic proximity Read ↗

Familial Mutations and Post-translational Modifications of UCH-L1 in Parkinson’s Disease and Neurodegenerative DisordersSemantic proximity Read ↗

Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration.Semantic proximity Read ↗

Mechanism of neurodegenerative disease: role of the ubiquitin proteasome systemSemantic proximity Read ↗

The ubiquitin proteasomal system: a potential target for the management of Alzheimer's diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.