Article

Glial Nrf2 signaling mediates the neuroprotection exerted by <i>Gastrodia elata</i> Blume in Lrrk2-G2019S Parkinson’s disease

2021-08-27

Abstract excerpt

The most frequent missense mutations in familial Parkinson’s disease (PD) occur in the highly conserved LRRK2/PARK8 gene with G2019S mutation. We previously established a fly model of PD carrying the LRRK2-G2019S mutation that exhibited the parkinsonism-like phenotypes. An herbal medicine— Gastrodia elata Blume (GE), has been reported to have neuroprotective effects in toxin- induced PD models. However, the und...

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Literature Corpus work: 66b3c371-c0a1-54a5-9cd4-30bbda89794c
DOI: 10.1101/2021.08.25.457612

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