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Article

Transgenic models of Huntington'sdisease

29 Jun 1999

Abstract excerpt

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by a CAG-polyglutamine repeat expansion. A mouse model of this disease has been generated by the introduction of exon 1 of the human HD gene carrying highly expanded CAG repeats into the mouse germ line (R6 lines). Transgenic mice develop a progressive neurological phenotype with a movement disorder and weight loss similar to that in HD....

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PMID: 10434294
DOI: 10.1098/rstb.1999.0447

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