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Article

Preliminary study on the mechanism of SAHA in the treatment of refractory epilepsy induced by GABRG2(F343L) mutation.

Biochemical pharmacology - 1 Sept 2024

Wang Jie, Wu Wenwen, Wan Jiali, Zhan Longwu, Chen Yuhan, Yun Feng, Ji Yuhua, Suo Guihai, Zheng Yuqin, Shen Dingding, Zhang Qi

Abstract excerpt

Mutations in the γ-amino butyric acid type A (GABAA) receptor γ2 subunit gene, GABRG2, have been associated with refractory epilepsy. Increasing evidence indicates that suberoylanilide hydroxamic acid (SAHA), a broad-spectrum histone acetyltransferases (HDACs) inhibitor, can inhibit seizure onset. However, the mechanisms involved remains unknown. The present study aimed to explore the anti-epileptic effect and...

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PMID: 39053637
DOI: 10.1016/j.bcp.2024.116449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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