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Article

Differential inflammation responses determine the variable phenotypes of epilepsy induced by GABRG2 mutations.

CNS neuroscience & therapeutics - 1 Feb 2024

Sui Jiahui, Zhan Longwu, Ji Shengtao, Wu Wenwen, Chen Yuhan, Yun Feng, Liang Wenpeng, Wang Jie, Cao Maohong, Shen Dingding, Zhang Qi

Abstract excerpt

OBJECTIVE: To explore the mechanism involved in variable phenotypes of epilepsy models induced by γ-aminobutyric acid type A γ2 subunit (GABRG2) mutations. METHODS: The zebrafish carrying wild-type (WT) GABRG2, mutant GABRG2(P282S), GABRG2(F343L) and GABRG2(I107T) were established by Tol2kit transgenesis system and Gateway method. Behavioral analysis of different transgenic zebrafish was performed with the...

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Identifiers

PMID: 38357846
DOI: 10.1111/cns.14583
PMCID: PMC10867793

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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