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Article

Quantifying Replication Slippage Error in Cryptosporidium Metabarcoding Studies.

The Journal of infectious diseases - 25 Jul 2024

Knox Matthew A, Biggs Patrick J, Garcia-R Juan Carlos, Hayman David T S

Abstract excerpt

Genetic variation in Cryptosporidium, a common protozoan gut parasite in humans, is often based on marker genes containing trinucleotide repeats, which differentiate subtypes and track outbreaks. However, repeat regions have high replication slippage rates, making it difficult to discern biological diversity from error. Here, we synthesized Cryptosporidium DNA in clonal plasmid vectors, amplified them in...

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Identifiers

PMID: 39052741
DOI: 10.1093/infdis/jiae065
PMCID: PMC11272095

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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