Article
A Risk Variant rs6922617 in TREM Is Discrepantly Associated With Defining Neuropathological Hallmarks in the Alzheimer's Continuum.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Sept 2024
Qian Shuangjie, Zheng Yi, Jiang Tao, Hou Jialong, Cao Ruixue, Cai Jinlai, Ma Enzi, Wang Wenwen, Song Weihong, Xie Chenglong
Abstract excerpt
The single nucleotide polymorphism (SNP)-rs6922617 in the triggering receptor expressed on myeloid cells (TREM) gene cluster is a potential risk factor for Alzheimer's disease (AD). Here, we examined whether rs6922617 is associated with AD-defining neuropathological hallmarks and memory performance. We assessed the interaction between the variant rs6922617 and levels of beta-amyloid (Aβ), tau pathology,...
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