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Article

Chromosomal missegregation and aberrant embryo development in repro57 female mice with Rnf212 homozygous mutation.

Reproduction (Cambridge, England) - 1 Oct 2024

Sono Nanami, Takeshita Mone, Chikushi Mizuho, Nakashima Saki, Miyawaki Shoko, Wakamatsu Misaki, Fujiwara Yasuhiro, Kunieda Tetsuo, Otsuki Junko

Abstract excerpt

In brief: Repro57 mice, bearing an Rnf212 gene mutation, exhibit infertility in both homozygous mutant males and females, revealing arrested spermatogenesis in males and investigating unclear mechanisms in females. The study highlights aneuploidy and altered kinetochore patterns in repro57 homozygous mutant oocytes, which impact later stages of embryo development. Abstract: Repro57 mice, induced with...

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PMID: 39042717
DOI: 10.1530/REP-24-0030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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