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Article

Leydig cell hyperplasia in an ENU-induced mutant mouse with germ cell depletion.

The Journal of reproduction and development - 1 Jun 2008

Khalaj Maryam, Abbasi Abdol Rahim, Nishimura Ryo, Akiyama Kouyou, Tsuji Takehito, Noguchi Junko, Okuda Kiyoshi, Kunieda Tetsuo

Abstract excerpt

Repro22 is an N-ethyl-N-nitrosourea (ENU)-induced mutation in mice showing depletion of both male and female germ cells. In the present study, we investigated the male phenotypes of the mutant mouse at the adult stage. The repro22/repro22 homozygous mice showed reduced body weights as well as markedly reduced testis weights. Histological examination of the testes at 4 and 10 months of age showed no germ cells in...

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Identifiers

PMID: 18385543
DOI: 10.1262/jrd.19191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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