Article
The expression of Y-linked Zfy2 in XY mouse oocytes leads to frequent meiosis 2 defects, a high incidence of subsequent early cleavage stage arrest and infertility.
Development (Cambridge, England) - 1 Feb 2014
Vernet Nadège, Szot Maria, Mahadevaiah Shantha K, Ellis Peter J I, Decarpentrie Fanny, Ojarikre Obah A, Rattigan Áine, Taketo Teruko, Burgoyne Paul S
Abstract excerpt
Outbred XY(Sry-) female mice that lack Sry due to the 11 kb deletion Sry(dl1Rlb) have very limited fertility. However, five lines of outbred XY(d) females with Y chromosome deletions Y(Del(Y)1Ct)-Y(Del(Y)5Ct) that deplete the Rbmy gene cluster and repress Sry transcription were found to be of good fertility. Here we tested our expectation that the difference in fertility between XO, XY(d-1) and XY(Sry-) females...
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