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Article

Mutagenesis-generated mouse models of human infertility with abnormal sperm.

Human reproduction (Oxford, England) - 1 Jan 2007

Lessard C, Lothrop H, Schimenti J C, Handel M A

Abstract excerpt

BACKGROUND: The aetiology of human male fertility, with impairment of sperm number, motility and morphology (oligoasthenoteratozoospermia), has been difficult to understand, partly for lack of animal models. METHODS: An ethylnitrosourea (ENU) mutagenesis strategy has been successful in producing heritable gene mutations with phenotypes similar to human male infertility, and here, we describe three independent...

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Source

Identifiers

PMID: 16920728
DOI: 10.1093/humrep/del322

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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