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Article

Plasma extrachromosomal circular DNA as a potential diagnostic biomarker for nodular thyroid disease

1 Jun 2024

Abstract excerpt

Dear Editor, The accurate diagnosis of cancerous nodules in nodular thyroid disease remains a significant challenge.1, 2 Extrachromosomal circular DNA (eccDNA), generated during apoptosis, shows tissue/plasma-specific patterns, and varying spectra in different diseases. However, its role in distinguishing benign and malignant thyroid nodules is unexplored.3-9 This study leverages Circle-seq technology and machine...

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PMID: 39031834
DOI: 10.1002/ctm2.1740

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