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Structural insights into an atypical histone binding mechanism by a PHD finger.

Structure (London, England : 1993) - 5 Sept 2024

Grégoire Sabrina, Grégoire Janelle, Yang Yidai, Capitani Sabrina, Joshi Monika, Sarvan Sabina, Zaker Arvin, Ning Zhibin, Figeys Daniel, Ulrich Kathrin, Brunzelle Joseph S, Mer Arvind, Couture Jean-Francois

Abstract excerpt

Complex associating with SET1 (COMPASS) is a histone H3K4 tri-methyltransferase controlled by several regulatory subunits including CXXC zinc finger protein 1 (Cfp1). Prior studies established the structural underpinnings controlling H3K4me3 recognition by the PHD domain of Cfp1's yeast homolog (Spp1). However, metazoans Cfp1PHD lacks structural elements important for H3K4me3 stabilization in Spp1, suggesting...

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PMID: 39029460
DOI: 10.1016/j.str.2024.06.017

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