Treponema pallidum genetic diversity and its implications for targeted vaccine development: A cross-sectional study of early syphilis cases in Southwestern Colombia.

doi:10.1371/journal.pone.0307600

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Article

Treponema pallidum genetic diversity and its implications for targeted vaccine development: A cross-sectional study of early syphilis cases in Southwestern Colombia.

PloS one - 1 Jan 2024

Salazar Juan C, Vargas-Cely Fabio, García-Luna Jonny A, Ramirez Lady G, Bettin Everton B, Romero-Rosas Nelson, Amórtegui María F, Silva Sebastián, Oviedo Oscar, Vigil Julie, La Vake Carson J, Galindo Ximena, Ramirez Jose D, Martínez-Valencia Alvaro J, Caimano Melissa J, Hennelly Christopher M, Aghakhanian Farhang, Moody M Anthony, Seña Arlene C, Parr Jonathan B, Hawley Kelly L, López-Medina Eduardo, Radolf Justin D

Abstract excerpt

BACKGROUND: Venereal syphilis, caused by the spirochete Treponema pallidum subsp. pallidum (TPA), is surging worldwide, underscoring the need for a vaccine with global efficacy. Vaccine development requires an understanding of syphilis epidemiology and clinical presentation as well as genomic characterization of TPA strains circulating within at-risk populations. The aim of this study was to describe the...

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PMID: 39028747
DOI: 10.1371/journal.pone.0307600
PMCID: PMC11259262

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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