Article
Oligoclonal CD4+CXCR5+ T cells with a cytotoxic phenotype appear in tonsils and blood.
Communications biology - 18 Jul 2024
Liang Chunguang, Spoerl Silvia, Xiao Yin, Habenicht Katharina M, Haeusl Sigrun S, Sandner Isabel, Winkler Julia, Strieder Nicholas, Eder Rüdiger, Stanewsky Hanna, Alexiou Christoph, Dudziak Diana, Rosenwald Andreas, Edinger Matthias, Rehli Michael, Hoffmann Petra, Winkler Thomas H, Berberich-Siebelt Friederike
Abstract excerpt
In clinical situations, peripheral blood accessible CD3+CD4+CXCR5+ T-follicular helper (TFH) cells may have to serve as a surrogate indicator for dysregulated germinal center responses in tissues. To determine the heterogeneity of TFH cells in peripheral blood versus tonsils, CD3+CD4+CD45RA-CXCR5+ cells of both origins were sorted. Transcriptomes, TCR repertoires and cell-surface protein expression were analysed...
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