Article
Fibrotic extracellular matrix impacts cardiomyocyte phenotype and function in an iPSC-derived isogenic model of cardiac fibrosis.
Translational research : the journal of laboratory and clinical medicine - 1 Nov 2024
Niro Francesco, Fernandes Soraia, Cassani Marco, Apostolico Monica, Oliver-De La Cruz Jorge, Pereira-Sousa Daniel, Pagliari Stefania, Vinarsky Vladimir, Zdráhal Zbyněk, Potesil David, Pustka Vaclav, Pompilio Giulio, Sommariva Elena, Rovina Davide, Maione Angela Serena, Bersanini Luca, Becker Malin, Rasponi Marco, Forte Giancarlo
Abstract excerpt
Cardiac fibrosis occurs following insults to the myocardium and is characterized by the abnormal accumulation of non-compliant extracellular matrix (ECM), which compromises cardiomyocyte contractile activity and eventually leads to heart failure. This phenomenon is driven by the activation of cardiac fibroblasts (cFbs) to myofibroblasts and results in changes in ECM biochemical, structural and mechanical...
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