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Article

Mechanical regulation of cardiac fibroblast profibrotic phenotypes.

Molecular biology of the cell - 7 Jul 2017

Herum Kate M, Choppe Jonas, Kumar Aditya, Engler Adam J, McCulloch Andrew D

Abstract excerpt

Cardiac fibrosis is a serious condition currently lacking effective treatments. It occurs as a result of cardiac fibroblast (CFB) activation and differentiation into myofibroblasts, characterized by proliferation, extracellular matrix (ECM) production and stiffening, and contraction due to the expression of smooth muscle α-actin. The mechanical properties of myocardium change regionally and over time after...

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Source

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Identifiers

PMID: 28468977
DOI: 10.1091/mbc.E17-01-0014
PMCID: PMC5541838

Genes

CFB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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